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P 18

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By Targets:	Phospholipase (1) Potassium Channel (1) Ras (1) Thrombin (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Inflammation/Immunology (2) Neurological Disease (1)

6

Inhibitors & Agonists

1

Peptides

10

Recombinant Proteins

5

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

P18IN003	Others	Inflammation/Immunology
P18IN003 is a potent *p18(INK4C)* inhibitor andspecifically block the activity of p18 protein. P18IN003 has the potential to be aneffective chemical agent for therapeutic expansion of HSC .

NSC23005 sodium 1 Publications Verification	Others	Cancer
NSC23005 sodium is a novel and effective *p18* inhibitor (ED₅₀=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.

DPTIP-prodrug 18 P18	Phospholipase	Inflammation/Immunology
DPTIP-proagent 18 (P18) is a orally active and brain-penetrable proagent of DPTIP (HY-131002). DPTIP-proagent 18 is a potent nSMase2 inhibitor. DPTIP-proagent 18 significantly inhibits IL-1β-induced EV (extracellular vesicle) release by inhibition of nSMase2 (neutral sphingomyelinase-2) activity. DPTIP-proagent 18 can be used for brain injury research .

HY-P4259

Hirullin P18

Thrombin Cardiovascular Disease

Hirullin P18 is a potent thrombin inhibitor. Hirullin P18 has an anticoagulant effect .
HY-144211

SOS1-IN-7

Ras Cancer

SOS1-IN-7 (compound 18-p1) is a potent SOS1 inhibitor with IC₅₀s of 20 and 67 nM for SOS1-G12D and SOS1-G12V, respectively .

A2764 dihydrochloride	Potassium Channel	Neurological Disease
A2764 dihydrochloride is a highly selective inhibitor of TRESK (TWIK-related spinal cord K ⁺ channel, K2P18.1), which has moderate inhibitory effects on TREK-1 and TALK-1. A2764 dihydrochloride is more sensitive to the activated mTRESK channels (IC₅₀=6.8 μM) than the basal current. A2764 dihydrochloride can lead to cell depolarization and increased excitability in native cells, it has the potential for probing the role of TRESK channel in migraine and nociception .

Species:	Human (10)
Tag:	His (9) GST (1)
Source:	E. coli (10)

Cat. No.	Compare	Product Name	Species	Source

	UBE2I Protein, Human (GST) SUMO-Conjugating Enzyme UBC9; SUMO-Protein Ligase; Ubiquitin Carrier Protein 9; Ubiquitin Carrier Protein I; Ubiquitin-Conjugating Enzyme E2 I; Ubiquitin-Protein Ligase I; p18; UBE2I; UBC9; UBCE9	Human	E. coli
	UBE2I Protein, a key participant in protein sumoylation, accepts ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4, and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex. Teaming up with E3 ligases like RANBP2, CBX4, and ZNF451, UBE2I catalyzes the covalent attachment of these SUMO proteins to target proteins, including critical substrates FOXL2 and KAT5. Its enzymatic activity extends to forming poly-SUMO chains, influencing diverse cellular processes and playing a pivotal role in specific protein modifications, such as sumoylation of p53/TP53 at 'Lys-386' and ERCC6. UBE2I Protein, Human (GST) is the recombinant human-derived UBE2I protein, expressed by E. coli, with N-GST labeled tag. The total length of UBE2I Protein, Human (GST) is 158 a.a., with molecular weight of ~40.0 kDa.

	LAMTOR1 Protein, Human (His) C11orf59; LAMTOR1; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; LTOR1_HUMAN; p18; p27Kip1-releasing factor from RhoA; p27RF-Rho; PDRO; PP7157; Protein associated with DRMs and endosomes; Ragulator complex protein LAMTOR1; ragulator complex protein PDRO; Ragulator1; RhoA activator C11orf59	Human	E. coli
	The LAMTOR1 protein is an important component of the Ragulator complex and plays dual roles in amino acid sensing and mTORC1 activation. It acts as a guanine nucleotide exchange factor (GEF) for Rag GTPases and mediates their recruitment to the lysosomal membrane. LAMTOR1 Protein, Human (His) is the recombinant human-derived LAMTOR1 protein, expressed by E. coli , with N-His labeled tag. The total length of LAMTOR1 Protein, Human (His) is 160 a.a., with molecular weight of ~24 kDa.

	EEF1E1 Protein, Human (His) Eukaryotic translation elongation factor 1 epsilon-1; AIMP3; P18	Human	E. coli
	The EEF1E1 protein is an important component of a multi-subunit complex that actively regulates the ATM response to DNA damage. It coordinates tRNA ligases of various amino acids and interacts with both MARS1 and EPRS1 in a core complex with AIMP2. EEF1E1 Protein, Human (His) is the recombinant human-derived EEF1E1 protein, expressed by E. coli , with N-His labeled tag. The total length of EEF1E1 Protein, Human (His) is 174 a.a., with molecular weight of 19-24 KDa.

	Cofilin-1 Protein, Human (His) Cofilin-1; 18 kDa phosphoprotein; p18; CFL1; CFL	Human	E. coli
	Cofilin-1 protein has pH-sensitive F-actin depolymerizing activity and can bind to F-actin. It cooperates with the subcortical maternal complex (SCMC) to guide the fertilized egg through initial embryonic cell division by regulating actin dynamics. Cofilin-1 Protein, Human (His) is the recombinant human-derived Cofilin-1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Cofilin-1 Protein, Human (His) is 166 a.a., with molecular weight of ~21 kDa.

	ZNHIT1 Protein, Human (His) inc finger HIT domain-containing protein 1; cyclin-G1-binding protein 1; zinc finger protein subfamily 4A member 1; p18 hamlet; CGBP1; ZNFN4A1; ZNHIT1	Human	E. coli
	ZNHIT1 is a key chromatin remodeling protein that regulates gene expression by promoting the incorporation of histone variants H2AZ1/H2A.Z. In muscle differentiation, ZNHIT1 is recruited to the MYOG promoter, mediating H2AZ1 binding and inducing muscle-specific gene expression. ZNHIT1 Protein, Human (His) is the recombinant human-derived ZNHIT1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ZNHIT1 Protein, Human (His) is 154 a.a., with molecular weight of ~21.0 kDa.

	CDKN2C Protein, Human (His) rHuCyclin-dependent kinase 4 inhibitor C/CDKN2C, His; Cyclin-Dependent Kinase 4 Inhibitor C; Cyclin-Dependent Kinase 6 Inhibitor; p18-INK4c; p18-INK6; CDKN2C; CDKN6	Human	E. coli
	The CDKN2C protein (also known as p18) interacts strongly with CDK6 and weakly with CDK4. Its functional effects inhibit cell growth and proliferation and are significantly related to the presence of endogenous retinoblastoma protein RB. CDKN2C Protein, Human (His) is the recombinant human-derived CDKN2C protein, expressed by E. coli , with N-6*His labeled tag. The total length of CDKN2C Protein, Human (His) is 168 a.a., with molecular weight of ~17.0 kDa.

	*Caspase-8/CASP8 subunit p18* Protein, Human (His)** ALPS2B; CASP-8; ICE-like apoptotic protease 5	Human	E. coli
	The Caspase-8/CASP8 subunit p18 protein is a key thiol protease that acts as a molecular switch in programmed cell death processes, including apoptosis, necroptosis, and pyroptosis. It is essential for preventing tissue damage by inducing exogenous apoptosis by cleaving and activating effector caspases. Caspase-8/CASP8 subunit p18 Protein, Human (His) is the recombinant human-derived Caspase-8/CASP8 subunit p18 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Caspase-8/CASP8 subunit p18 Protein, Human (His) is 158 a.a., with molecular weight of ~21.9 kDa.

	Stathmin Protein, Human (C-His) Stathmin; Leukemia-Associated Phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17; STMN1; C1orf215; LAP18; OP18	Human	E. coli
	Stathmin proteins critically regulate the microtubule filament system by actively destabilizing microtubules, inhibiting assembly, and promoting disassembly. Phosphorylation of Ser-16 is critical for axon formation during neurogenesis, highlighting its importance in neuronal development. Stathmin Protein, Human (C-His) is the recombinant human-derived Stathmin protein, expressed by E. coli , with C-6*His labeled tag. The total length of Stathmin Protein, Human (C-His) is 148 a.a., with molecular weight of ~20.0 kDa.

	Stathmin Protein, Human (His) "Stathmin; Leukemia-Associated Phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17; STMN1; C1orf215; LAP18; OP18 "	Human	E. coli
	Stathmin Protein, a widely distributed cytosolic phosphoprotein, integrates regulatory signals and destabilizes microtubules, crucial for their assembly and disassembly. It exhibits broad expression in various tissues, highlighting its versatile role in cellular processes. Stathmin Protein, Human (His) is the recombinant human-derived Stathmin protein, expressed by E. coli , with N-6*His labeled tag. The total length of Stathmin Protein, Human (His) is 149 a.a., with molecular weight of ~19 kDa.

	TPPP2 Protein, Human (His) Tubulin polymerization-promoting protein family member 2; Protein p25-beta; TPPP/p18; C14orf8	Human	E. coli
	The TPPP2 protein may be a regulator of microtubule dynamics and is critical for sperm motility. Unlike other family members, TPPP2 lacks microtubule bundling activity, suggesting a unique functional role. TPPP2 Protein, Human (His) is the recombinant human-derived TPPP2 protein, expressed by E. coli , with N-His labeled tag. The total length of TPPP2 Protein, Human (His) is 170 a.a., with molecular weight of 18-21 kDa.

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